Probabilistic approach to the design of symmetric protein quaternary structures

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Probabilistic approach to the design of symmetric protein quaternary structures.

Probabilistic methods have been developed that estimate the site-specific probabilities of the amino acids in sequences likely to fold to a particular target structure, and such information can be used to guide the de novo design of proteins and to probe sequence variability. An extension of these methods for the design of symmetric homo-oligomeric quaternary structures is presented. The theory...

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ژورنال

عنوان ژورنال: Protein Engineering Design and Selection

سال: 2003

ISSN: 1741-0126,1741-0134

DOI: 10.1093/protein/gzg132